※ DYRK family introduction

    DYRK (Dual-specificity tyrosine-regulated kinase) belong to CMGC family. Homology within the kinase domain can further classify this family into three subfamilies: DYRK kinases, homeodomain-interacting protein kinases (HIPKs), and pre-mRNA processing protein 4 kinases (PRP4s). Ten members have been found in human genome. DYRKs are characterized as dual-specificity protein kinases for their ability to mediate the phosphorylation of serine, threonine and tyrosine residues; however, the tyrosine phosphorylation activity is restricted to autophosphorylation. DYRKs play an important role and act as pleiotropic regulators in a variety of cellular functions, including cell survival, cell differentiation, gene transcription and endocytosis. Mutation or abnormal expressions always associate with diseases. Truncation mutants of DYRK1A result in clinical phenotypes, including microcephaly, intrauterine growth retardation, and developmental delay. Overexpression of DYRK1B has been reported in solid tumors, including colon and lung cancer, pancreatic ductal adenocarcinomas, and rhabdomyosarcomas, and experimental data suggest that increased amounts of DYRK1B favor tumor development (1).

Reference
1. Aranda, S., Laguna, A. and de la Luna, S. (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J, 25, 449-462. PMID: 21048044

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GLM-00092	GLYMA16G34510
2		EKS-GLM-00088	GLYMA14G06420
3		EKS-GLM-00090	GLYMA08G06160
4		EKS-GLM-00085	GLYMA16G18183
5		EKS-GLM-00084	GLYMA08G35243
6		EKS-GLM-00091	GLYMA05G33560
7		EKS-GLM-00087	GLYMA10G42220
8		EKS-GLM-00086	GLYMA20G24820
9		EKS-GLM-00093	GLYMA09G29970
10		EKS-GLM-00095	GLYMA01G20811
11		EKS-GLM-00094	GLYMA04G21250
12		EKS-GLM-00096	GLYMA19G35800
13		EKS-GLM-00089	GLYMA02G42460