※ DYRK family introduction

    DYRK (Dual-specificity tyrosine-regulated kinase) belong to CMGC family. Homology within the kinase domain can further classify this family into three subfamilies: DYRK kinases, homeodomain-interacting protein kinases (HIPKs), and pre-mRNA processing protein 4 kinases (PRP4s). Ten members have been found in human genome. DYRKs are characterized as dual-specificity protein kinases for their ability to mediate the phosphorylation of serine, threonine and tyrosine residues; however, the tyrosine phosphorylation activity is restricted to autophosphorylation. DYRKs play an important role and act as pleiotropic regulators in a variety of cellular functions, including cell survival, cell differentiation, gene transcription and endocytosis. Mutation or abnormal expressions always associate with diseases. Truncation mutants of DYRK1A result in clinical phenotypes, including microcephaly, intrauterine growth retardation, and developmental delay. Overexpression of DYRK1B has been reported in solid tumors, including colon and lung cancer, pancreatic ductal adenocarcinomas, and rhabdomyosarcomas, and experimental data suggest that increased amounts of DYRK1B favor tumor development (1).

Reference
1. Aranda, S., Laguna, A. and de la Luna, S. (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J, 25, 449-462. PMID: 21048044

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-POT-00988	POPTR_0012s03680
2		EKS-POT-00986	POPTR_0008s11780
3		EKS-POT-00985	POPTR_0019s06030	POPTRDRAFT_242255
4		EKS-POT-00992	POPTR_0013s07270
5		EKS-POT-00990	POPTR_0008s06890	POPTRDRAFT_820414
6		EKS-POT-00991	POPTR_0015s05150
7		EKS-POT-00987	POPTR_0010s13690	POPTRDRAFT_769666
8		EKS-POT-00989	POPTR_0010s19570	POPTRDRAFT_1091811