※ DYRK family introduction

    DYRK (Dual-specificity tyrosine-regulated kinase) belong to CMGC family. Homology within the kinase domain can further classify this family into three subfamilies: DYRK kinases, homeodomain-interacting protein kinases (HIPKs), and pre-mRNA processing protein 4 kinases (PRP4s). Ten members have been found in human genome. DYRKs are characterized as dual-specificity protein kinases for their ability to mediate the phosphorylation of serine, threonine and tyrosine residues; however, the tyrosine phosphorylation activity is restricted to autophosphorylation. DYRKs play an important role and act as pleiotropic regulators in a variety of cellular functions, including cell survival, cell differentiation, gene transcription and endocytosis. Mutation or abnormal expressions always associate with diseases. Truncation mutants of DYRK1A result in clinical phenotypes, including microcephaly, intrauterine growth retardation, and developmental delay. Overexpression of DYRK1B has been reported in solid tumors, including colon and lung cancer, pancreatic ductal adenocarcinomas, and rhabdomyosarcomas, and experimental data suggest that increased amounts of DYRK1B favor tumor development (1).

Reference
1. Aranda, S., Laguna, A. and de la Luna, S. (2011) DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles. FASEB J, 25, 449-462. PMID: 21048044

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEM-00619	SELMODRAFT_90432	SELMODRAFT_90432
2		EKS-SEM-00616	SELMODRAFT_2004	SELMODRAFT_2004
3		EKS-SEM-00617	SELMODRAFT_2003	SELMODRAFT_2003
4		EKS-SEM-00618	SELMODRAFT_2002	SELMODRAFT_2002
5		EKS-SEM-00613	SELMODRAFT_43152	SELMODRAFT_43152
6		EKS-SEM-00620	SELMODRAFT_100581	SELMODRAFT_100581
7		EKS-SEM-00610	SELMODRAFT_410118	SELMODRAFT_410118
8		EKS-SEM-00612	SELMODRAFT_111790	SELMODRAFT_111790
9		EKS-SEM-00609	SELMODRAFT_73320	SELMODRAFT_73320
10		EKS-SEM-00621	SELMODRAFT_95819	SELMODRAFT_95819
11		EKS-SEM-00615	SELMODRAFT_86693	SELMODRAFT_86693
12		EKS-SEM-00611	SELMODRAFT_118517	SELMODRAFT_118517; SELMODRAFT_100748, SELMODRAFT_118517
13		EKS-SEM-00614	SELMODRAFT_75107	SELMODRAFT_75107