※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

  Reviewed (0)  or Unreviewed (7) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-HOV-00889	MLOC_11953
2		EKS-HOV-00893	MLOC_79033
3		EKS-HOV-00888	MLOC_36539
4		EKS-HOV-00891	MLOC_71014
5		EKS-HOV-00890	MLOC_68311
6		EKS-HOV-00887	MLOC_72662
7		EKS-HOV-00892	MLOC_52139