※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

  Reviewed (0)  or Unreviewed (7) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-PHP-00635	PP1S306_43V6	PHYPADRAFT_197781; Q6VM07_9BRYO
2		EKS-PHP-00639	PP1S391_47V6	PHYPADRAFT_61509; A9TZV6_PHYPA
3		EKS-PHP-00634	PP1S74_168V6	A9SFW7_PHYPA; PHYPADRAFT_211896
4		EKS-PHP-00636	PP1S306_62V6	PHYPADRAFT_197793; A9TSI8_PHYPA
5		EKS-PHP-00637	PP1S60_100V6	PHYPADRAFT_210224; Q6VM14_9BRYO
6		EKS-PHP-00638	PP1S60_85V6	A9SAB0_PHYPA; PHYPADRAFT_163779
7		EKS-PHP-00633	PP1S52_55V6	PHYPADRAFT_105861; A9S6L2_PHYPA