Populus trichocarpa      CMGC      GSK

※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387


There are 10 genes.  Reviewed (0 or Unreviewed (10

No.StatusEKPD IDGene IDGene Name
1
EKS-POT-01615
POPTR_0002s19110
POPTRDRAFT_830470
2
EKS-POT-01617
POPTR_0002s15640
POPTRDRAFT_644407
3
EKS-POT-01616
POPTR_0014s07120
POPTRDRAFT_663875
4
EKS-POT-01619
POPTR_0011s07130
POPTRDRAFT_822933
5
EKS-POT-01621
POPTR_0004s23420
6
EKS-POT-01613
POPTR_0013s00610
7
EKS-POT-01614
POPTR_0005s00710
POPTRDRAFT_581623
8
EKS-POT-01618
POPTR_0004s05770
9
EKS-POT-01622
POPTR_0022s00480
10
EKS-POT-01620
POPTR_0022s00490