※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SOT-00980	PGSC0003DMG402000517	PGSC0003DMG402000517
2		EKS-SOT-00986	PGSC0003DMG400026744	PGSC0003DMG400026744
3		EKS-SOT-00985	PGSC0003DMG400006989	PGSC0003DMG400006989
4		EKS-SOT-00983	PGSC0003DMG400020436	PGSC0003DMG400020436
5		EKS-SOT-00981	PGSC0003DMG400002747	PGSC0003DMG400002747
6		EKS-SOT-00982	PGSC0003DMG400027771	PGSC0003DMG400027771
7		EKS-SOT-00987	PGSC0003DMG400024885	PGSC0003DMG400024885
8		EKS-SOT-00979	PGSC0003DMG400031389	PGSC0003DMG400031389
9		EKS-SOT-00984	PGSC0003DMG400028428	PGSC0003DMG400028428