Vitis vinifera      CMGC      GSK

※ GSK family introduction

    GSK (Glycogen synthase kinase 3) belong to CMGC family. Two isoforms have been identified in human genome, known as GSK3A and GSK3B. GSKs are highly conserved and have been found in nearly all eukaryote. Sequence analysis show that two genes display 85% sequence identity, and even higher in the catalytic domain (93%). Chromosomal mapping identified the cytological location of human GSK3A as 19q13.2, whereas human GSK3B maps to 3q13.3. Northern blot analysis shows that GSKs are expressed in different mammalian tissues. GSKs play an important role in a variety of cellular signaling pathways, including cellular proliferation, migration, inflammation and immue responses, glucose regulation and apoptosis (1).

Reference
3. Ali, A., Hoeflich, K.P. and Woodgett, J.R. (2001) Glycogen synthase kinase-3: properties, functions, and regulation. Chem Rev, 101, 2527-2540. PMID: 11749387


There are 7 genes.  Reviewed (0 or Unreviewed (7

No.StatusEKPD IDGene IDGene Name
1
EKS-VIV-01123
Vv07s0005g02100
VITISV_017659
2
EKS-VIV-01124
Vv15s0048g02010
VIT_15s0048g02010
3
EKS-VIV-01122
Vv10s0003g01480
VIT_10s0003g01480
4
EKS-VIV-01120
Vv12s0035g01060
VIT_12s0035g01060
5
EKS-VIV-01125
Vv12s0028g01810
VIT_12s0028g01810
6
EKS-VIV-01119
Vv14s0060g00600
VIT_14s0060g00600
7
EKS-VIV-01121
Vv14s0066g01050
VIT_14s0066g01050