※ CDC14 family introduction

    CDC14 phosphatase belongs to a family of highly conserved DUSP phosphatase. All CDC14 family members share a conserved N-terminal core domain, in which two subdomain contribute to critical function, one is involved in substrate specificity and another subdomain act as the phosphatase catalytic domain. The C-terminal domain of CDC14 family is variable which might be involved in subcellular localization. CDC14 family is a key regulator in cell cycle and they are characterized by controlling exit from mitosis. CDC14 is well understood in budding yeast Saccharomyces cerevisiae and studies show that ScCDC14 plays an important role in DNA replication, mitotic exit and cytokinesis. In Saccharomyces pombe CDC14-Like phosphatase, also known as Clp1, participates in G2−M transition and cytokinesis. In mammals, human CDC14B is important in regulating centriole duplication, cell cycle progression, mitotic exit, DNA damage and DNA repair (1).

Reference
1. Mocciaro, A. and Schiebel, E. (2010) Cdc14: a highly conserved family of phosphatases with non-conserved functions? J Cell Sci, 123, 2867-2876. PMID: 20720150

  Reviewed (0)  or Unreviewed (4) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-GOG-00044	ENSGGOG00000027917	ENSG00000081377
2		EPS-GOG-00043	ENSGGOG00000008986	CDC14B
3		EPS-GOG-00042	ENSGGOG00000006770	CDC14A
4		EPS-GOG-00045	ENSGGOG00000024707	ENSG00000158079