※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-BRD-00016	BRADI2G49300	BRADI2G49300
2		EPS-BRD-00018	BRADI4G44490	BRADI4G44490
3		EPS-BRD-00013	BRADI3G33430	BRADI3G33430
4		EPS-BRD-00012	BRADI4G43490	BRADI4G43490
5		EPS-BRD-00017	BRADI4G22137	BRADI4G22137
6		EPS-BRD-00020	BRADI3G34990	BRADI3G34990
7		EPS-BRD-00019	BRADI4G40600	BRADI4G40600
8		EPS-BRD-00015	BRADI2G46150	BRADI2G46150
9		EPS-BRD-00014	BRADI3G53590	BRADI3G53590
10		EPS-BRD-00021	BRADI1G78040	BRADI1G78040