※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-BRR-00014	Bra006908	Bra006908
2		EPS-BRR-00007	Bra017303	Bra017303
3		EPS-BRR-00016	Bra023024	Bra023024
4		EPS-BRR-00005	Bra009705	Bra009705
5		EPS-BRR-00011	Bra029881	Bra029881
6		EPS-BRR-00010	Bra029747	Bra029747
7		EPS-BRR-00008	Bra005315	Bra005315
8		EPS-BRR-00015	Bra009992	Bra009992
9		EPS-BRR-00013	Bra005691	Bra005691
10		EPS-BRR-00006	Bra026842	Bra026842
11		EPS-BRR-00012	Bra033449	Bra033449
12		EPS-BRR-00009	Bra002803	Bra002803