※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-ECT-00009	ENSETEG00000015510	DUSP3
2		EPS-ECT-00006	ENSETEG00000013484	DUSP13
3		EPS-ECT-00007	ENSETEG00000004883
4		EPS-ECT-00011	ENSETEG00000006587	DUSP12
5		EPS-ECT-00008	ENSETEG00000013086	DUSP21
6		EPS-ECT-00010	ENSETEG00000011289	DUSP22
7		EPS-ECT-00012	ENSETEG00000016745	EPM2A
8		EPS-ECT-00013	ENSETEG00000005304	DUSP11
9		EPS-ECT-00014	ENSETEG00000018008	RNGTT