※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-FEC-00011	ENSFCAG00000004098	DUSP18
2		EPS-FEC-00020	ENSFCAG00000019224	DUSP11
3		EPS-FEC-00013	ENSFCAG00000031413
4		EPS-FEC-00009	ENSFCAG00000005553	DUPD1
5		EPS-FEC-00015	ENSFCAG00000001052	DUSP27
6		EPS-FEC-00019	ENSFCAG00000008168	DUSP12
7		EPS-FEC-00018	ENSFCAG00000001901	DUSP15
8		EPS-FEC-00016	ENSFCAG00000010571	DUSP14
9		EPS-FEC-00023	ENSFCAG00000030695
10		EPS-FEC-00014	ENSFCAG00000005072	DUSP13
11		EPS-FEC-00022	ENSFCAG00000022512	DUSP23
12		EPS-FEC-00012	ENSFCAG00000029357	DUSP21
13		EPS-FEC-00021	ENSFCAG00000011712	EPM2A
14		EPS-FEC-00017	ENSFCAG00000014458	DUSP22
15		EPS-FEC-00010	ENSFCAG00000006331	DUSP26