※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-MUP-00009	ENSMPUG00000009658	Dusp3
2		EPS-MUP-00002	ENSMPUG00000010124	Dusp26
3		EPS-MUP-00014	ENSMPUG00000003938	Ptpmt1
4		EPS-MUP-00005	ENSMPUG00000018962	DUSP21
5		EPS-MUP-00012	ENSMPUG00000018056	EPM2A
6		EPS-MUP-00015	ENSMPUG00000017099
7		EPS-MUP-00013	ENSMPUG00000007736	Dusp11
8		EPS-MUP-00007	ENSMPUG00000015676	Dusp27
9		EPS-MUP-00011	ENSMPUG00000003487	Dusp12
10		EPS-MUP-00008	ENSMPUG00000019626	DUSP14
11		EPS-MUP-00004	ENSMPUG00000003289
12		EPS-MUP-00003	ENSMPUG00000003311	Dupd1
13		EPS-MUP-00010	ENSMPUG00000007855	Dusp22
14		EPS-MUP-00006	ENSMPUG00000019455	DUSP18