※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-OCP-00008	ENSOPRG00000007348	DUSP28
2		EPS-OCP-00006	ENSOPRG00000015540	DUSP21
3		EPS-OCP-00004	ENSOPRG00000012664	DUSP22
4		EPS-OCP-00010	ENSOPRG00000018742	PTPMT1
5		EPS-OCP-00003	ENSOPRG00000006796	DUSP3
6		EPS-OCP-00009	ENSOPRG00000014610	DUSP11
7		EPS-OCP-00005	ENSOPRG00000002366	DUPD1
8		EPS-OCP-00007	ENSOPRG00000013888	DUSP12
9		EPS-OCP-00011	ENSOPRG00000011681