※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-ORA-00017	ENSOANG00000010174	STYXL1
2		EPS-ORA-00009	ENSOANG00000005909	DUSP13
3		EPS-ORA-00018	ENSOANG00000000533	RNGTT
4		EPS-ORA-00014	ENSOANG00000031368	DUPD1
5		EPS-ORA-00011	ENSOANG00000007135	DUSP14
6		EPS-ORA-00013	ENSOANG00000014901	DUSP22
7		EPS-ORA-00010	ENSOANG00000006350	LOC100092717
8		EPS-ORA-00012	ENSOANG00000006826	DUSP28
9		EPS-ORA-00008	ENSOANG00000002390	DUSP26
10		EPS-ORA-00015	ENSOANG00000002508	EPM2A
11		EPS-ORA-00016	ENSOANG00000007893	PTPMT1