※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-ORB-00015	OB11G15440	OB11G15440
2		EPS-ORB-00021	OB08G21170	OB08G21170
3		EPS-ORB-00014	OB10G25670	OB10G25670
4		EPS-ORB-00008	OB12G12250	OB12G12250
5		EPS-ORB-00011	OB05G30870	OB05G30870
6		EPS-ORB-00016	OB06G20890	OB06G20890
7		EPS-ORB-00020	OB03G10600	OB03G10600
8		EPS-ORB-00018	OB11G10530	OB11G10530
9		EPS-ORB-00012	OB06G13150	OB06G13150
10		EPS-ORB-00009	OB11G11940	OB11G0080L20_7; Ob11g0080L20_7
11		EPS-ORB-00017	OB12G10780	OB12G10780
12		EPS-ORB-00010	OB02G37590	OB02G37590
13		EPS-ORB-00013	OB01G39210	OB01G39210
14		EPS-ORB-00019	OB12G15240	OB12G15240