※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-PEM-00015	ENSPMAG00000005449	RNGTT
2		EPS-PEM-00007	ENSPMAG00000001249	DUSP3
3		EPS-PEM-00009	ENSPMAG00000008454	DUSP28
4		EPS-PEM-00011	ENSPMAG00000005832	DUSP11
5		EPS-PEM-00012	ENSPMAG00000000221	STYXL1
6		EPS-PEM-00014	ENSPMAG00000005907	PTPMT1
7		EPS-PEM-00006	ENSPMAG00000005935	DUSP22
8		EPS-PEM-00013	ENSPMAG00000005762	DUSP23
9		EPS-PEM-00008	ENSPMAG00000010435
10		EPS-PEM-00010	ENSPMAG00000002067	DUPD1