※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-PHP-00008	PP1S121_164V6	PHYPADRAFT_84283; A9SUV5_PHYPA
2		EPS-PHP-00013	PP1S144_24V6
3		EPS-PHP-00011	PP1S31_1V6	A9RVT1_PHYPA; PHYPADRAFT_161212
4		EPS-PHP-00009	PP1S18_297V6	A9RNE0_PHYPA; PHYPADRAFT_117078
5		EPS-PHP-00010	PP1S130_137V6	A9SWX1_PHYPA; PHYPADRAFT_234308
6		EPS-PHP-00012	PP1S341_30V6	A9TW13_PHYPA; PHYPADRAFT_151647