※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-POT-00012	POPTR_0006s03870	POPTRDRAFT_560396
2		EPS-POT-00013	POPTR_0014s04500	POPTRDRAFT_1110136
3		EPS-POT-00019	POPTR_0006s09720	POPTRDRAFT_1080718
4		EPS-POT-00015	POPTR_0003s07780	POPTRDRAFT_413796
5		EPS-POT-00017	POPTR_0001s34940
6		EPS-POT-00011	POPTR_0016s03490	POPTRDRAFT_576161
7		EPS-POT-00016	POPTR_0001s15460
8		EPS-POT-00020	POPTR_0010s23850	POPTRDRAFT_1092626
9		EPS-POT-00014	POPTR_0002s13750	POPTRDRAFT_409955
10		EPS-POT-00022	POPTR_0019s07510	POPTRDRAFT_573846
11		EPS-POT-00021	POPTR_0008s02930
12		EPS-POT-00018	POPTR_0016s11810	POPTRDRAFT_735714