※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-PTV-00006	ENSPVAG00000004371	DUSP21
2		EPS-PTV-00012	ENSPVAG00000012420	DUSP11
3		EPS-PTV-00005	ENSPVAG00000015113	DUSP18
4		EPS-PTV-00014	ENSPVAG00000015390	DUSP23
5		EPS-PTV-00008	ENSPVAG00000003109	DUSP3
6		EPS-PTV-00011	ENSPVAG00000001950	DUSP28
7		EPS-PTV-00010	ENSPVAG00000005073	DUSP22
8		EPS-PTV-00009	ENSPVAG00000010455	DUSP14
9		EPS-PTV-00007	ENSPVAG00000009605	DUSP13
10		EPS-PTV-00003	ENSPVAG00000009604	DUPD1
11		EPS-PTV-00013	ENSPVAG00000007341	PTPMT1
12		EPS-PTV-00004	ENSPVAG00000004700	DUSP26