※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SEM-00016	SELMODRAFT_132412	SELMODRAFT_132412
2		EPS-SEM-00011	SELMODRAFT_133537	SELMODRAFT_133537
3		EPS-SEM-00012	SELMODRAFT_127483	SELMODRAFT_127483
4		EPS-SEM-00017	SELMODRAFT_100916	SELMODRAFT_100916
5		EPS-SEM-00005	SELMODRAFT_97017	SELMODRAFT_97017
6		EPS-SEM-00008	SELMODRAFT_6246	SELMODRAFT_6246
7		EPS-SEM-00007	SELMODRAFT_6245	SELMODRAFT_6245
8		EPS-SEM-00009	SELMODRAFT_36819	SELMODRAFT_36819
9		EPS-SEM-00010	SELMODRAFT_36823	SELMODRAFT_36823
10		EPS-SEM-00013	SELMODRAFT_35954	SELMODRAFT_35954
11		EPS-SEM-00014	SELMODRAFT_35953	SELMODRAFT_35953
12		EPS-SEM-00015	SELMODRAFT_118282	SELMODRAFT_118282
13		EPS-SEM-00006	SELMODRAFT_180850	SELMODRAFT_180850
14		EPS-SEM-00018	SELMODRAFT_34445	SELMODRAFT_34445