※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SEI-00017	Si018046m.g	Si018046m.g
2		EPS-SEI-00014	Si026860m.g	Si026860m.g
3		EPS-SEI-00013	Si002138m.g	Si002138m.g
4		EPS-SEI-00019	Si013457m.g	Si013457m.g
5		EPS-SEI-00018	Si035550m.g	Si035550m.g
6		EPS-SEI-00016	Si026743m.g	Si026743m.g
7		EPS-SEI-00010	Si007116m.g	Si007116m.g
8		EPS-SEI-00011	Si022411m.g	Si022411m.g
9		EPS-SEI-00012	Si036426m.g	Si036426m.g
10		EPS-SEI-00015	Si026068m.g	Si026068m.g