※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SOL-00018	Solyc11g007830.1	PTPKIS1; ptpkis1
2		EPS-SOL-00021	Solyc11g040180.1	Solyc11g040180.1
3		EPS-SOL-00015	Solyc10g039280.1	Solyc10g039280.1
4		EPS-SOL-00012	Solyc12g021180.1	Solyc12g021180.1
5		EPS-SOL-00019	Solyc03g111160.2	Solyc03g111160.2
6		EPS-SOL-00013	Solyc08g078270.2	Solyc08g078270.2
7		EPS-SOL-00014	Solyc06g066760.2	Solyc06g066760.2
8		EPS-SOL-00020	Solyc09g065010.2	Solyc09g065010.2
9		EPS-SOL-00011	Solyc00g185750.1	Solyc00g185750.1
10		EPS-SOL-00016	Solyc12g008620.1	Solyc12g008620.1
11		EPS-SOL-00017	Solyc09g011930.2	Solyc09g011930.2