※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SOT-00019	PGSC0003DMG400015246	PGSC0003DMG400015246
2		EPS-SOT-00013	PGSC0003DMG400016539	PGSC0003DMG400016539
3		EPS-SOT-00020	PGSC0003DMG400027327	PGSC0003DMG400027327
4		EPS-SOT-00015	PGSC0003DMG400004324	PGSC0003DMG400004324
5		EPS-SOT-00016	PGSC0003DMG400000351	PGSC0003DMG400000351
6		EPS-SOT-00014	PGSC0003DMG400026263	PGSC0003DMG400026263
7		EPS-SOT-00017	PGSC0003DMG400030092	PGSC0003DMG400030092
8		EPS-SOT-00018	PGSC0003DMG400029073	PGSC0003DMG400029073