※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

  Reviewed (0)  or Unreviewed (8) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-SOB-00010	Sb03g034070	SORBIDRAFT_03g034070; Sb03g034070; SB03G034070
2		EPS-SOB-00008	Sb10g003660	Sb10g003660; SB10G003660; SORBIDRAFT_10g003660
3		EPS-SOB-00011	Sb01g028980	SB01G028980; SORBIDRAFT_01g028980; Sb01g028980
4		EPS-SOB-00009	Sb09g026140	SB09G026140; Sb09g026140; SORBIDRAFT_09g026140
5		EPS-SOB-00012	Sb05g008670	SORBIDRAFT_05g008670; SB05G008670; Sb05g008670
6		EPS-SOB-00013	Sb08g002770	Sb08g002770; SB08G002770; SORBIDRAFT_08g002770
7		EPS-SOB-00014	Sb07g019250	Sb07g019250; SORBIDRAFT_07g019250; SB07G019250
8		EPS-SOB-00007	Sb05g002140	Sb05g002140; SB05G002140; SORBIDRAFT_05g002140