※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-TUT-00013	ENSTTRG00000001792	DUSP23
2		EPS-TUT-00010	ENSTTRG00000001848	DUSP22
3		EPS-TUT-00006	ENSTTRG00000010224	DUSP18
4		EPS-TUT-00009	ENSTTRG00000008915	DUSP14
5		EPS-TUT-00005	ENSTTRG00000012995	DUSP26
6		EPS-TUT-00011	ENSTTRG00000007932	DUSP15
7		EPS-TUT-00014	ENSTTRG00000015444	DUSP11
8		EPS-TUT-00012	ENSTTRG00000012138	DUSP12
9		EPS-TUT-00007	ENSTTRG00000005101	DUSP3
10		EPS-TUT-00008	ENSTTRG00000008525	DUSP27