※ aDSP family introduction

    aDSP (Atypical DSP) family contains phosphatases which are poorly characterized, they are smaller than MKP family and lack specific MAP kinase motifs (1). Family member DUSP3 is invloved in down-regulating the ERK pathway and specifically dephosphorylates and inactivates ERK1 and ERK2 (2). DUSP11 show phosphatase activity towards RNA 5'-triphosphatase and may participate in nuclear mrna metabolism. The studies show that most of aDSP phosphatase have function unrelated to MAP kinases (3).

Reference
1. Alonso, A., Sasin, J., Bottini, N., Friedberg, I., Osterman, A., Godzik, A., Hunter, T., Dixon, J. and Mustelin, T. (2004) Protein tyrosine phosphatases in the human genome. Cell, 117, 699-711. PMID:15186772
2. Todd, J.L., Tanner, K.G. and Denu, J.M. (1999) Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. J Biol Chem, 274, 13271-13280. PMID: 10224087
3. Yuan, Y., Li, D.M. and Sun, H. (1998) PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes. J Biol Chem, 273, 20347-20353. PMID: 9685386

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-VIV-00015	Vv13s0067g02510	VIT_13s0067g02510
2		EPS-VIV-00012	Vv08s0007g01780	VIT_08s0007g01780
3		EPS-VIV-00014	Vv00s0250g00020	VITISV_036073
4		EPS-VIV-00013	Vv14s0066g01200	VIT_14s0066g01200
5		EPS-VIV-00008	Vv08s0040g01270	VIT_08s0040g01270
6		EPS-VIV-00011	Vv15s0021g01850	VIT_15s0021g01850
7		EPS-VIV-00010	Vv00s0341g00010	VIT_00s0341g00010
8		EPS-VIV-00009	Vv11s0016g02890	VIT_11s0016g02890