※ IKK family introduction

    IKKs family contains four members, IKKα, IKKβ and two IKK-related kinases, IKKε and NAK, which have been identified with sequence similarity to IKKα and IKKβ. Sequence analysis of IKKs shows that IKKα and IKKβ contain a kinase catalytic domain in its N-terminal and followed by three function motif, known as LZ(leucine zipper), HLH(helix-loop-helix) and NBD(NEMO-binding domain). Activation of IKKs is associated with NF-κB signaling pathway which is triggered by different receptors, including members of TNFR family, members of the IL-1R and Toll-Like receptor (TLR) family and antigen receptors. All IKKs are implicated in the regulation of NF-κB activity and IKKs act as key regulator in various physiological and pathophysiological functions including host defense response, inflammation, cell survival, cancer, metabolic regulation, and neuroadaptation (1).

Reference
1. Hacker, H. and Karin, M. (2006) Regulation and function of IKK and IKK-related kinases. Sci STKE, 2006, re13. PMID: 17047224

  Reviewed (0)  or Unreviewed (3) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GOG-00293	ENSGGOG00000006786	TBK1
2		EKS-GOG-00291	ENSGGOG00000006769	IKBKB
3		EKS-GOG-00292	ENSGGOG00000015253	IKBKE