※ NEK family introduction

    NEKs (Never in mitosis A-related kinases) are classified into "Other" group. Eleven members have been identified in human genome. NimA is the founding member of the NEK family of ser/thr kinases which is an essential regulator of mitosis. All NEK kinases except NEK10 contain N-terminal catalytic domain, followed by coiled-coiled motifs except in NEK4,6 and 7 members. And in C-terminal, PEST sequences are found in moreover 6 of 11 NEK kinases. Besides the homology regions, certain NEKs contain unique domain or sequences, such as RCC1 repeats, DEAD-box helicase-like domain and armadillo repeats. NEKs play an important role in a variety of cellular processes and functions via mediate the phosphorylation of substrates. Studies show that NEK2 is essential in control of centrosome splitting, NEK6, 7 and 9 have been found in regulating mitotic spindle and cytokinesis, NEK1 and NEK8 is related to ciliagenesis. NEKs act as key regulator function during mitosis and abnormal expression or mutations on NEKs gene will lead to some disease and cancers such ovarian cancer, lung cancer, breast cancer and so on (1).

Reference
1. Moniz, L., Dutt, P., Haider, N. and Stambolic, V. (2011) Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div, 6, 18. PMID: 22040655

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GAA-00429	ENSGACG00000014071	NEK1
2		EKS-GAA-00434	ENSGACG00000018308	NEK6
3		EKS-GAA-00438	ENSGACG00000018419
4		EKS-GAA-00433	ENSGACG00000011167	NEK8
5		EKS-GAA-00436	ENSGACG00000007632	NEK9
6		EKS-GAA-00432	ENSGACG00000007977	NEK5
7		EKS-GAA-00430	ENSGACG00000007863	NEK7
8		EKS-GAA-00431	ENSGACG00000000316	NEK4
9		EKS-GAA-00437	ENSGACG00000011936	NEK3
10		EKS-GAA-00435	ENSGACG00000009916	NEK2