※ NEK family introduction

    NEKs (Never in mitosis A-related kinases) are classified into "Other" group. Eleven members have been identified in human genome. NimA is the founding member of the NEK family of ser/thr kinases which is an essential regulator of mitosis. All NEK kinases except NEK10 contain N-terminal catalytic domain, followed by coiled-coiled motifs except in NEK4,6 and 7 members. And in C-terminal, PEST sequences are found in moreover 6 of 11 NEK kinases. Besides the homology regions, certain NEKs contain unique domain or sequences, such as RCC1 repeats, DEAD-box helicase-like domain and armadillo repeats. NEKs play an important role in a variety of cellular processes and functions via mediate the phosphorylation of substrates. Studies show that NEK2 is essential in control of centrosome splitting, NEK6, 7 and 9 have been found in regulating mitotic spindle and cytokinesis, NEK1 and NEK8 is related to ciliagenesis. NEKs act as key regulator function during mitosis and abnormal expression or mutations on NEKs gene will lead to some disease and cancers such ovarian cancer, lung cancer, breast cancer and so on (1).

Reference
1. Moniz, L., Dutt, P., Haider, N. and Stambolic, V. (2011) Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div, 6, 18. PMID: 22040655

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GLM-00264	GLYMA19G32470
2		EKS-GLM-00274	GLYMA10G03470
3		EKS-GLM-00277	GLYMA02G31110
4		EKS-GLM-00270	GLYMA03G40620
5		EKS-GLM-00275	GLYMA19G43290
6		EKS-GLM-00269	GLYMA12G31330
7		EKS-GLM-00276	GLYMA02G16350
8		EKS-GLM-00263	GLYMA03G29640
9		EKS-GLM-00273	GLYMA10G30330
10		EKS-GLM-00268	GLYMA19G34170
11		EKS-GLM-00272	GLYMA13G38980
12		EKS-GLM-00267	GLYMA11G18340
13		EKS-GLM-00266	GLYMA12G09910
14		EKS-GLM-00271	GLYMA20G36690
15		EKS-GLM-00265	GLYMA03G31330
16		EKS-GLM-00279	GLYMA06G15570
17		EKS-GLM-00278	GLYMA10G12361