※ NEK family introduction

    NEKs (Never in mitosis A-related kinases) are classified into "Other" group. Eleven members have been identified in human genome. NimA is the founding member of the NEK family of ser/thr kinases which is an essential regulator of mitosis. All NEK kinases except NEK10 contain N-terminal catalytic domain, followed by coiled-coiled motifs except in NEK4,6 and 7 members. And in C-terminal, PEST sequences are found in moreover 6 of 11 NEK kinases. Besides the homology regions, certain NEKs contain unique domain or sequences, such as RCC1 repeats, DEAD-box helicase-like domain and armadillo repeats. NEKs play an important role in a variety of cellular processes and functions via mediate the phosphorylation of substrates. Studies show that NEK2 is essential in control of centrosome splitting, NEK6, 7 and 9 have been found in regulating mitotic spindle and cytokinesis, NEK1 and NEK8 is related to ciliagenesis. NEKs act as key regulator function during mitosis and abnormal expression or mutations on NEKs gene will lead to some disease and cancers such ovarian cancer, lung cancer, breast cancer and so on (1).

Reference
1. Moniz, L., Dutt, P., Haider, N. and Stambolic, V. (2011) Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div, 6, 18. PMID: 22040655

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-LOA-00359	ENSLAFG00000016078	NEK4
2		EKS-LOA-00363	ENSLAFG00000007538	NEK10
3		EKS-LOA-00358	ENSLAFG00000005184	NEK7
4		EKS-LOA-00360	ENSLAFG00000000026	NEK3
5		EKS-LOA-00357	ENSLAFG00000021394	NEK6
6		EKS-LOA-00365	ENSLAFG00000012436	NEK11
7		EKS-LOA-00366	ENSLAFG00000032725
8		EKS-LOA-00362	ENSLAFG00000013150	NEK9
9		EKS-LOA-00361	ENSLAFG00000013390	NEK8
10		EKS-LOA-00356	ENSLAFG00000015115	NEK2
11		EKS-LOA-00364	ENSLAFG00000003382	NEK5