※ NEK family introduction

    NEKs (Never in mitosis A-related kinases) are classified into "Other" group. Eleven members have been identified in human genome. NimA is the founding member of the NEK family of ser/thr kinases which is an essential regulator of mitosis. All NEK kinases except NEK10 contain N-terminal catalytic domain, followed by coiled-coiled motifs except in NEK4,6 and 7 members. And in C-terminal, PEST sequences are found in moreover 6 of 11 NEK kinases. Besides the homology regions, certain NEKs contain unique domain or sequences, such as RCC1 repeats, DEAD-box helicase-like domain and armadillo repeats. NEKs play an important role in a variety of cellular processes and functions via mediate the phosphorylation of substrates. Studies show that NEK2 is essential in control of centrosome splitting, NEK6, 7 and 9 have been found in regulating mitotic spindle and cytokinesis, NEK1 and NEK8 is related to ciliagenesis. NEKs act as key regulator function during mitosis and abnormal expression or mutations on NEKs gene will lead to some disease and cancers such ovarian cancer, lung cancer, breast cancer and so on (1).

Reference
1. Moniz, L., Dutt, P., Haider, N. and Stambolic, V. (2011) Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div, 6, 18. PMID: 22040655

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-MOD-00341	ENSMODG00000028479	NEK5
2		EKS-MOD-00345	ENSMODG00000005989	NEK9
3		EKS-MOD-00343	ENSMODG00000012789	NEK7
4		EKS-MOD-00347	ENSMODG00000014978	NEK10
5		EKS-MOD-00339	ENSMODG00000002981	NEK1
6		EKS-MOD-00344	ENSMODG00000002788	NEK2
7		EKS-MOD-00342	ENSMODG00000019741	NEK6
8		EKS-MOD-00340	ENSMODG00000011196	NEK4
9		EKS-MOD-00346	ENSMODG00000011910	NEK11