※ NEK family introduction

    NEKs (Never in mitosis A-related kinases) are classified into "Other" group. Eleven members have been identified in human genome. NimA is the founding member of the NEK family of ser/thr kinases which is an essential regulator of mitosis. All NEK kinases except NEK10 contain N-terminal catalytic domain, followed by coiled-coiled motifs except in NEK4,6 and 7 members. And in C-terminal, PEST sequences are found in moreover 6 of 11 NEK kinases. Besides the homology regions, certain NEKs contain unique domain or sequences, such as RCC1 repeats, DEAD-box helicase-like domain and armadillo repeats. NEKs play an important role in a variety of cellular processes and functions via mediate the phosphorylation of substrates. Studies show that NEK2 is essential in control of centrosome splitting, NEK6, 7 and 9 have been found in regulating mitotic spindle and cytokinesis, NEK1 and NEK8 is related to ciliagenesis. NEKs act as key regulator function during mitosis and abnormal expression or mutations on NEKs gene will lead to some disease and cancers such ovarian cancer, lung cancer, breast cancer and so on (1).

Reference
1. Moniz, L., Dutt, P., Haider, N. and Stambolic, V. (2011) Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div, 6, 18. PMID: 22040655

  Reviewed (1)  or Unreviewed (9) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SUS-00308	ENSSSCG00000015604	NEK2
2		EKS-SUS-00316	ENSSSCG00000010904	NEK7
3		EKS-SUS-00309	ENSSSCG00000009380	NEK5
4		EKS-SUS-00310	ENSSSCG00000009379	NEK3
5		EKS-SUS-00307	ENSSSCG00000009714	NEK1
6		EKS-SUS-00311	ENSSSCG00000005587	NEK6
7		EKS-SUS-00312	ENSSSCG00000017766	NEK8
8		EKS-SUS-00313	ENSSSCG00000002381	NEK9
9		EKS-SUS-00314	ENSSSCG00000011446	NEK4
10		EKS-SUS-00315	ENSSSCG00000011217	NEK10