※ NEK family introduction

    NEKs (Never in mitosis A-related kinases) are classified into "Other" group. Eleven members have been identified in human genome. NimA is the founding member of the NEK family of ser/thr kinases which is an essential regulator of mitosis. All NEK kinases except NEK10 contain N-terminal catalytic domain, followed by coiled-coiled motifs except in NEK4,6 and 7 members. And in C-terminal, PEST sequences are found in moreover 6 of 11 NEK kinases. Besides the homology regions, certain NEKs contain unique domain or sequences, such as RCC1 repeats, DEAD-box helicase-like domain and armadillo repeats. NEKs play an important role in a variety of cellular processes and functions via mediate the phosphorylation of substrates. Studies show that NEK2 is essential in control of centrosome splitting, NEK6, 7 and 9 have been found in regulating mitotic spindle and cytokinesis, NEK1 and NEK8 is related to ciliagenesis. NEKs act as key regulator function during mitosis and abnormal expression or mutations on NEKs gene will lead to some disease and cancers such ovarian cancer, lung cancer, breast cancer and so on (1).

Reference
1. Moniz, L., Dutt, P., Haider, N. and Stambolic, V. (2011) Nek family of kinases in cell cycle, checkpoint control and cancer. Cell Div, 6, 18. PMID: 22040655

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAG-00430	ENSTGUG00000004189	NEK11
2		EKS-TAG-00424	ENSTGUG00000004374	NEK7
3		EKS-TAG-00427	ENSTGUG00000007095	NEK6
4		EKS-TAG-00428	ENSTGUG00000003146	NEK2
5		EKS-TAG-00431	ENSTGUG00000012213	NEK9
6		EKS-TAG-00426	ENSTGUG00000012048	NEK3
7		EKS-TAG-00423	ENSTGUG00000012059	NEK5
8		EKS-TAG-00429	ENSTGUG00000006190	NEK8
9		EKS-TAG-00422	ENSTGUG00000006124	NEK1
10		EKS-TAG-00425	ENSTGUG00000005727	NEK4
11		EKS-TAG-00432	ENSTGUG00000017228	NEK4