※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (12) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ARL-00928	fgenesh1_pm.C_scaffold_3000372	XM_002882336.1
2		EKS-ARL-00932	fgenesh2_kg.5__1508__AT3G51630.1	XM_002876050.1
3		EKS-ARL-00931	fgenesh2_kg.6__2776__AT5G28080.2	XM_002874372.1
4		EKS-ARL-00935	Al_scaffold_0008_2174	XM_002866146.1
5		EKS-ARL-00924	fgenesh2_kg.1__4012__AT1G49160.2	XM_002894116.1
6		EKS-ARL-00930	fgenesh2_kg.8__1766__AT5G58350.1	XM_002864519.1
7		EKS-ARL-00934	Al_scaffold_0002_13	XM_002887823.1
8		EKS-ARL-00933	fgenesh2_kg.8__1460__AT5G55560.1	XM_002866057.1
9		EKS-ARL-00925	Al_scaffold_0003_2404	XM_002883317.1
10		EKS-ARL-00927	fgenesh1_pm.C_scaffold_3001651	XM_002885231.1
11		EKS-ARL-00929	Al_scaffold_0005_1640	XM_002877560.1
12		EKS-ARL-00926	fgenesh2_kg.7__3219__AT5G41992.1	XM_002868522.1