※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (11)  or Unreviewed (0) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-ART-00925	AT3G18750	WNK6; ZIK5; At3g18750; MVE11.20
2		EKS-ART-00935	AT5G55560	WNK11; At5g55560; AT5G55560; MWC10.1
3		EKS-ART-00934	AT3G51630	ATWNK5; WNK5; At3g51630; T18N14.10
4		EKS-ART-00932	AT5G28080	WNK9; T24G3.10; At5g28080
5		EKS-ART-00927	AT3G22420	At3g22420; MCB17.15; ATWNK2; WNK2
6		EKS-ART-00930	AT3G48260	At3g48260; WNK3; T29H11_220
7		EKS-ART-00931	AT3G04910	T9J14.14; WNK1; At3g04910
8		EKS-ART-00926	AT1G49160	F27J15.7; WNK7; At1g49160
9		EKS-ART-00928	AT5G41990	MJC20.9; WNK8; At5g41990
10		EKS-ART-00933	AT5G58350	MCK7.22; WNK4; At5g58350
11		EKS-ART-00929	AT1G64630	WNK10; F1N19.20; At1g64630; ATWNK10