※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-BRD-01057	BRADI4G44427	BRADI4G44427
2		EKS-BRD-01059	BRADI4G41940	BRADI4G41940
3		EKS-BRD-01054	BRADI3G51457	BRADI3G51457
4		EKS-BRD-01056	BRADI2G39347	BRADI2G39347
5		EKS-BRD-01058	BRADI1G23320	BRADI1G23320
6		EKS-BRD-01055	BRADI1G23970	BRADI1G23970