※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (29) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-GLM-00233	GLYMA18G44761	WNK11
2		EKS-GLM-00223	GLYMA04G36260	WNK3
3		EKS-GLM-00247	GLYMA11G26210
4		EKS-GLM-00221	GLYMA07G05930	WNK6
5		EKS-GLM-00245	GLYMA10G12051
6		EKS-GLM-00226	GLYMA03G40550
7		EKS-GLM-00244	GLYMA08G43750
8		EKS-GLM-00220	GLYMA16G02531
9		EKS-GLM-00231	GLYMA10G39390
10		EKS-GLM-00227	GLYMA19G43210	WNK9
11		EKS-GLM-00224	GLYMA13G10480
12		EKS-GLM-00234	GLYMA02G40200	WNK12
13		EKS-GLM-00243	GLYMA18G09070
14		EKS-GLM-00222	GLYMA20G16430	WNK8
15		EKS-GLM-00238	GLYMA03G04450	WNK5
16		EKS-GLM-00236	GLYMA14G38390
17		EKS-GLM-00242	GLYMA02G46670
18		EKS-GLM-00241	GLYMA14G02000
19		EKS-GLM-00228	GLYMA20G37180	WNK1
20		EKS-GLM-00237	GLYMA01G32450
21		EKS-GLM-00230	GLYMA20G28411
22		EKS-GLM-00229	GLYMA10G30211
23		EKS-GLM-00232	GLYMA09G41270	WNK10
24		EKS-GLM-00225	GLYMA06G18630	WNK7
25		EKS-GLM-00246	GLYMA05G32281
26		EKS-GLM-00235	GLYMA18G06076
27		EKS-GLM-00240	GLYMA02G47670
28		EKS-GLM-00219	GLYMA06G15610
29		EKS-GLM-00239	GLYMA14G00986