※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (16) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-POT-01679	POPTR_0010s23190
2		EKS-POT-01676	POPTR_0019s14910	POPTRDRAFT_1108693
3		EKS-POT-01678	POPTR_0014s16200	POPTRDRAFT_807663
4		EKS-POT-01677	POPTR_0008s03700	POPTRDRAFT_419647
5		EKS-POT-01671	POPTR_0010s09830
6		EKS-POT-01674	POPTR_0008s15170	POPTRDRAFT_1085371
7		EKS-POT-01664	POPTR_0001s11210	POPTRDRAFT_1066545
8		EKS-POT-01672	POPTR_0030s00490	POPTRDRAFT_1096507
9		EKS-POT-01667	POPTR_0015s09610	POPTRDRAFT_1101454
10		EKS-POT-01675	POPTR_0013s15110	POPTRDRAFT_571883
11		EKS-POT-01669	POPTR_0012s08860	POPTRDRAFT_806487
12		EKS-POT-01673	POPTR_0016s14210
13		EKS-POT-01668	POPTR_0014s09700	POPTRDRAFT_899714
14		EKS-POT-01666	POPTR_0003s14520	POPTRDRAFT_554544
15		EKS-POT-01670	POPTR_0005s05140	POPTRDRAFT_294801
16		EKS-POT-01665	POPTR_0005s05860	POPTRDRAFT_294641