※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SEM-00929	SELMODRAFT_130367	SELMODRAFT_130367
2		EKS-SEM-00933	SELMODRAFT_136322	SELMODRAFT_136322
3		EKS-SEM-00927	SELMODRAFT_126389	SELMODRAFT_126389
4		EKS-SEM-00928	SELMODRAFT_126444	SELMODRAFT_126444
5		EKS-SEM-00930	SELMODRAFT_134163	SELMODRAFT_134163
6		EKS-SEM-00931	SELMODRAFT_11342	SELMODRAFT_11342
7		EKS-SEM-00932	SELMODRAFT_134331	SELMODRAFT_134331