※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SOL-00957	Solyc06g071800.2	Solyc06g071800.2
2		EKS-SOL-00956	Solyc10g009350.2	Solyc10g009350.2
3		EKS-SOL-00961	Solyc01g097840.2	Solyc01g097840.2
4		EKS-SOL-00959	Solyc09g076000.2	Solyc09g076000.2
5		EKS-SOL-00966	Solyc07g047990.1	Solyc07g047990.1
6		EKS-SOL-00970	Solyc00g153680.1	Solyc00g153680.1
7		EKS-SOL-00969	Solyc02g087590.1	Solyc02g087590.1
8		EKS-SOL-00963	Solyc06g082470.2	Solyc06g082470.2
9		EKS-SOL-00962	Solyc08g082980.2	Solyc08g082980.2
10		EKS-SOL-00965	Solyc07g065250.2	Solyc07g065250.2
11		EKS-SOL-00958	Solyc03g112140.2	Solyc03g112140.2
12		EKS-SOL-00967	Solyc05g041420.2	Solyc05g041420.2
13		EKS-SOL-00968	Solyc10g009060.1	Solyc10g009060.1
14		EKS-SOL-00960	Solyc01g096170.2	Solyc01g096170.2
15		EKS-SOL-00964	Solyc09g018170.2	Solyc09g018170.2