※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (13) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-SOT-01025	PGSC0003DMG402012244	PGSC0003DMG402012244
2		EKS-SOT-01028	PGSC0003DMG400022188	PGSC0003DMG400022188
3		EKS-SOT-01023	PGSC0003DMG400018191	PGSC0003DMG400018191
4		EKS-SOT-01030	PGSC0003DMG400006134	PGSC0003DMG400006134
5		EKS-SOT-01031	PGSC0003DMG400047254	PGSC0003DMG400047254
6		EKS-SOT-01032	PGSC0003DMG400036177	PGSC0003DMG400036177
7		EKS-SOT-01027	PGSC0003DMG400004415	PGSC0003DMG400004415
8		EKS-SOT-01024	PGSC0003DMG400022507	PGSC0003DMG400022507
9		EKS-SOT-01033	PGSC0003DMG400022825	PGSC0003DMG400022825
10		EKS-SOT-01021	PGSC0003DMG400000122	PGSC0003DMG400000122
11		EKS-SOT-01029	PGSC0003DMG400030274	PGSC0003DMG400030274
12		EKS-SOT-01026	PGSC0003DMG400030463	PGSC0003DMG400030463
13		EKS-SOT-01022	PGSC0003DMG400030087	PGSC0003DMG400030087