※ WNK family introduction

    WNK family kinase are serine/threonine kinase and are classified into Others family. Four genes have been found encoding the WNK kinases in human genome, WNK1-4. WNKs function diversity in different cells and tissues. Studies show that WNKs regulate three sodium transportes, including NKCC2, NCC and ENaC. What's more, WNKs can regulate aldosterone-regulated renal outer medullary potassium channel (ROMK). WNKs can also be regarded as molecular switches that modify tansporter acitvity depending on physiological demands. Furthermore, WNKs also appear to be part of a larger kinase network, such as Ste20-related kinase SPAK and serum and glucocorticoid inducible kinase 1 (SGK1). Mutations or abnormal expression will lead to familial hyperkalemic hypertension (1).

Reference
1. Hoorn, E.J. and Ellison, D.H. (2012) WNK kinases and the kidney. Exp Cell Res, 318, 1020-1026. PMID: 22405999.

  Reviewed (0)  or Unreviewed (7) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-TAR-00119	ENSTRUG00000013549	WNK2 (2 of 2)
2		EKS-TAR-00115	ENSTRUG00000012158	WNK1 (1 of 2)
3		EKS-TAR-00113	ENSTRUG00000014958	WNK3
4		EKS-TAR-00117	ENSTRUG00000006558	WNK4 (1 of 2)
5		EKS-TAR-00114	ENSTRUG00000009590	WNK2 (1 of 2)
6		EKS-TAR-00116	ENSTRUG00000016493	WNK1 (2 of 2)
7		EKS-TAR-00118	ENSTRUG00000004395	WNK4 (2 of 2)