※ PP2C family introduction

    Metal-dependent protein phosphatases (PPM), includes protein phosphatases which dependent on manganese/magnesium ions (Mn2+/Mg2+). PPM family contains a high conserved catalytic domain instead of catalytic subunit and different regulatory domains determine the substrate recognition and function diversity. Like PPP family, metal ions play an important role in dephosphorylation reaction (1). PP2C contains 19 members in human genome, including PP2C like phosphatases. What's more, PP2C is the largest protein phosphatases in plants with at least 76 members in Arabidopsis thaliana. PP2C family members are involved in varieties of cellular processes including cell cycle, splicing, cellular stress signaling and some members function as tumor suppressor proteins (2).

Reference
1. Shi, Y. (2009) Serine/threonine phosphatases: mechanism through structure. Cell, 139, 468-484. PMID: 19879837
2. Lammers, T. and Lavi, S. (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol, 42, 437-461. PMID: 18066953

  Reviewed (0)  or Unreviewed (6) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-DIO-00013	ENSDORG00000006785	Ppm1g
2		EPS-DIO-00001	ENSDORG00000010344	Pptc7
3		EPS-DIO-00012	ENSDORG00000001261	Ppm1k
4		EPS-DIO-00014	ENSDORG00000007916	Ppm1h
5		EPS-DIO-00010	ENSDORG00000007776	Ppm1a
6		EPS-DIO-00011	ENSDORG00000008921	Ilkap