Drosophila melanogaster      PPP      PP1

※ PP1 family introduction

    PP1 enzyme is composed of a catalytic subunit and a regulatory subunit(R subunit), and the catalytic domain is conserved among all eukaryotes, more than 100 regulatory subunit have been found to interact with C domain. Therefore, PP1 is a functional diversity protein phosphatases, which regulates a varieties of cellular processes through dephosphorylate different substrate. PP1 can promote the rational use of energy, especially when nutrients are abundant. PP1 plays a key role in the recovery from stress but promotes apoptosis when cells are damaged beyond repair. In addition, PP1 can regulate the cell cycle (1).

Reference
1. Ceulemans, H. and Bollen, M. (2004) Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev, 84, 1-39. PMID: 14715909


There are 9 genes.  Reviewed (5 or Unreviewed (4

No.StatusEKPD IDGene IDGene Name
1
EPS-DRM-00070
FBgn0003140
PpD19, PPY; CG10930; PpY-55A
2
EPS-DRM-00067
FBgn0003134
Pp1-96A; CG6593; Pp1alpha-96A
3
EPS-DRM-00068
FBgn0003132
Pp1-13C; CG9156
4
EPS-DRM-00074
FBgn0261399
Pp1rY1, Pp1Y1; Pp1-Y1
5
EPS-DRM-00073
FBgn0025573
PpN58A; CG3245; PPN 58A
6
EPS-DRM-00072
FBgn0005779
PpD6
7
EPS-DRM-00071
FBgn0005778
Dmel_CG10138; PpD5-RA; PpD5
8
EPS-DRM-00069
FBgn0000711
flw; PP1-9C, PP1-BETA-9C; CG2096
9
EPS-DRM-00066
FBgn0004103
Pp1-87B; CG5650