※ PP1 family introduction

    PP1 enzyme is composed of a catalytic subunit and a regulatory subunit(R subunit), and the catalytic domain is conserved among all eukaryotes, more than 100 regulatory subunit have been found to interact with C domain. Therefore, PP1 is a functional diversity protein phosphatases, which regulates a varieties of cellular processes through dephosphorylate different substrate. PP1 can promote the rational use of energy, especially when nutrients are abundant. PP1 plays a key role in the recovery from stress but promotes apoptosis when cells are damaged beyond repair. In addition, PP1 can regulate the cell cycle (1).

Reference
1. Ceulemans, H. and Bollen, M. (2004) Functional diversity of protein phosphatase-1, a cellular economizer and reset button. Physiol Rev, 84, 1-39. PMID: 14715909

  Reviewed (0)  or Unreviewed (3) 

No.	Status	EKPD ID	Gene ID	Gene Name
1		EPS-GOG-00068	ENSGGOG00000009981	PPP1CA
2		EPS-GOG-00069	ENSGGOG00000011663	PPP1CC
3		EPS-GOG-00070	ENSGGOG00000014347	PPP1CB