Xenopus tropicalis PPP PP6※ PP6 family introduction PP6, a family of PPP, is highly conserved in evolution. PP6 phosphatase is composed of a catalytic subunit, a SAPS regulatory subunits and an ankyrin repeat subunits. The three SAPS regulatory subunits are distinct in sequence and function diversity. PP6 play an important role in signaling pathway such as NFkB signaling pathway, and act as a regulator of cell cycle progression (1). The N terminal domain can restrict G1 to S phase progression (2).
Reference
1. Mi, J., Dziegielewski, J., Bolesta, E., Brautigan, D.L. and Larner, J.M. (2009) Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6. PLoS One, 4, e4395. PMID: 19198648
2. Stefansson, B. and Brautigan, D.L. (2007) Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells. Cell Cycle, 6, 1386-1392. PMID: 17568194
There are 1 genes. Reviewed (0)
or Unreviewed (1) 
1. Mi, J., Dziegielewski, J., Bolesta, E., Brautigan, D.L. and Larner, J.M. (2009) Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6. PLoS One, 4, e4395. PMID: 19198648
2. Stefansson, B. and Brautigan, D.L. (2007) Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells. Cell Cycle, 6, 1386-1392. PMID: 17568194
There are 1 genes. Reviewed (0)
or Unreviewed (1) | No. | Status | EKPD ID | Gene ID | Gene Name |
|---|---|---|---|---|
| 1 | |