Callithrix jacchus PSP-Other Caspy/SIP※ Caspy/SIP family introduction SIP (CacyBP/SIP) was originally identified in Ehrilich ascities tumor cells. SIP has been show to interact with a variety of ligands, including S100, Skp1, tubulin, Siah-1, actin and ERK1/2. Studies show that binding with tubulin is essential for cytoskeleton rearrangement during the differentiation of NB2a cells. SIP interacts with ERK1/2 will lead to the ELK-1 activation and plays an important role in cell differentiation. SIP has also been found to contain phosphatase activity recently and one substrate is ERK1/2. E217K mutant will lead to the drop of phosphatase activity toward ERK1/2, which suggests that the C-terminal domain act as a phosphatase like domain (1).
Reference
1. Kilanczyk, E., Filipek, S. and Filipek, A. (2011) ERK1/2 is dephosphorylated by a novel phosphatase--CacyBP/SIP. Biochem Biophys Res Commun, 404, 179-183. PMID: 21110948
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1. Kilanczyk, E., Filipek, S. and Filipek, A. (2011) ERK1/2 is dephosphorylated by a novel phosphatase--CacyBP/SIP. Biochem Biophys Res Commun, 404, 179-183. PMID: 21110948
There are 1 genes. Reviewed (0)
or Unreviewed (1) | No. | Status | EKPD ID | Gene ID | Gene Name |
|---|---|---|---|---|
| 1 | |