※ STE20 family introduction

    STE20 was first identified as a putative MAP4K in mating pathway in yeast and its homologs in human constitute a large family in STE group. STE20 can further be classified into two subclasses, PAK and GCK. Structure analysis shows that the kinase domains in PAKs are located at C-terminal while GCKs kinase domains are located in N-terminal. Three mammalian STE20-like kinases have been reported to be able to phosphorylate MAP3Ks, including HPK1, GLK and PAK2. HPK1 predominantly mediate the activation of the stress-activated SAPK/JNK pathway. PAK2 is activated via binding of the Rac1 or Cdc42 and subsequently involved in direct phosphorylation of MAP3K Raf-1. Besides as a upstream activator of MAPK pathway, STE20 are often used in signaling events, including cell apoptosis, morphogenesis and cytoskeletal rearrangement such as cell motility and cell shape changes (1).

Reference
1. Dan, I., Watanabe, N.M. and Kusumi, A. (2001) The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol, 11, 220-230. PMID: 11316611

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No.	Status	EKPD ID	Gene ID	Gene Name
1		EKS-BRD-01052	BRADI3G38300	BRADI3G38300
2		EKS-BRD-01047	BRADI1G42257	BRADI1G42257
3		EKS-BRD-01053	BRADI3G05890	BRADI3G05890
4		EKS-BRD-01050	BRADI1G08287	BRADI1G08287
5		EKS-BRD-01049	BRADI3G31110	BRADI3G31110
6		EKS-BRD-01048	BRADI3G53837	BRADI3G53837
7		EKS-BRD-01051	BRADI1G77700	BRADI1G77700
8		EKS-BRD-01046	BRADI1G26670	BRADI1G26670